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Effects of E. lenta and P. <t>excrementihominis</t> on PC. ( a-b ) Demo diagram illustrating pancreas and spleen, and statistical histograms showing pancreas weight and pancreas-to-body weight ratios in mice gavaged with E. lenta ( E. l ), P. excrementihominis ( P. e ), or PBS ( n = 8 per group). The orthotopic PC model was established using Panc02 cells. ( c-d ) Demo diagram illustrating the full body, pancreas and spleen, and statistical histogram showing the fluorescent area with intensity greater than 200 photons/second (ph/s), representing pancreatic tumors in mice gavaged with E. lenta, P. excrementihominis , or PBS ( n = 8 per group). The orthotopic PC model was established using luciferase-expressing KPC1199 cells. Data are presented as mean ± SD; * P < 0.05; ** P < 0.01 by unpaired Student’s t -test
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Effects of E. lenta and P. <t>excrementihominis</t> on PC. ( a-b ) Demo diagram illustrating pancreas and spleen, and statistical histograms showing pancreas weight and pancreas-to-body weight ratios in mice gavaged with E. lenta ( E. l ), P. excrementihominis ( P. e ), or PBS ( n = 8 per group). The orthotopic PC model was established using Panc02 cells. ( c-d ) Demo diagram illustrating the full body, pancreas and spleen, and statistical histogram showing the fluorescent area with intensity greater than 200 photons/second (ph/s), representing pancreatic tumors in mice gavaged with E. lenta, P. excrementihominis , or PBS ( n = 8 per group). The orthotopic PC model was established using luciferase-expressing KPC1199 cells. Data are presented as mean ± SD; * P < 0.05; ** P < 0.01 by unpaired Student’s t -test
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Effects of E. lenta and P. <t>excrementihominis</t> on PC. ( a-b ) Demo diagram illustrating pancreas and spleen, and statistical histograms showing pancreas weight and pancreas-to-body weight ratios in mice gavaged with E. lenta ( E. l ), P. excrementihominis ( P. e ), or PBS ( n = 8 per group). The orthotopic PC model was established using Panc02 cells. ( c-d ) Demo diagram illustrating the full body, pancreas and spleen, and statistical histogram showing the fluorescent area with intensity greater than 200 photons/second (ph/s), representing pancreatic tumors in mice gavaged with E. lenta, P. excrementihominis , or PBS ( n = 8 per group). The orthotopic PC model was established using luciferase-expressing KPC1199 cells. Data are presented as mean ± SD; * P < 0.05; ** P < 0.01 by unpaired Student’s t -test
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Effects of E. lenta and P. <t>excrementihominis</t> on PC. ( a-b ) Demo diagram illustrating pancreas and spleen, and statistical histograms showing pancreas weight and pancreas-to-body weight ratios in mice gavaged with E. lenta ( E. l ), P. excrementihominis ( P. e ), or PBS ( n = 8 per group). The orthotopic PC model was established using Panc02 cells. ( c-d ) Demo diagram illustrating the full body, pancreas and spleen, and statistical histogram showing the fluorescent area with intensity greater than 200 photons/second (ph/s), representing pancreatic tumors in mice gavaged with E. lenta, P. excrementihominis , or PBS ( n = 8 per group). The orthotopic PC model was established using luciferase-expressing KPC1199 cells. Data are presented as mean ± SD; * P < 0.05; ** P < 0.01 by unpaired Student’s t -test
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Effects of E. lenta and P. <t>excrementihominis</t> on PC. ( a-b ) Demo diagram illustrating pancreas and spleen, and statistical histograms showing pancreas weight and pancreas-to-body weight ratios in mice gavaged with E. lenta ( E. l ), P. excrementihominis ( P. e ), or PBS ( n = 8 per group). The orthotopic PC model was established using Panc02 cells. ( c-d ) Demo diagram illustrating the full body, pancreas and spleen, and statistical histogram showing the fluorescent area with intensity greater than 200 photons/second (ph/s), representing pancreatic tumors in mice gavaged with E. lenta, P. excrementihominis , or PBS ( n = 8 per group). The orthotopic PC model was established using luciferase-expressing KPC1199 cells. Data are presented as mean ± SD; * P < 0.05; ** P < 0.01 by unpaired Student’s t -test
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Effects of E. lenta and P. <t>excrementihominis</t> on PC. ( a-b ) Demo diagram illustrating pancreas and spleen, and statistical histograms showing pancreas weight and pancreas-to-body weight ratios in mice gavaged with E. lenta ( E. l ), P. excrementihominis ( P. e ), or PBS ( n = 8 per group). The orthotopic PC model was established using Panc02 cells. ( c-d ) Demo diagram illustrating the full body, pancreas and spleen, and statistical histogram showing the fluorescent area with intensity greater than 200 photons/second (ph/s), representing pancreatic tumors in mice gavaged with E. lenta, P. excrementihominis , or PBS ( n = 8 per group). The orthotopic PC model was established using luciferase-expressing KPC1199 cells. Data are presented as mean ± SD; * P < 0.05; ** P < 0.01 by unpaired Student’s t -test
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Effects of E. lenta and P. excrementihominis on PC. ( a-b ) Demo diagram illustrating pancreas and spleen, and statistical histograms showing pancreas weight and pancreas-to-body weight ratios in mice gavaged with E. lenta ( E. l ), P. excrementihominis ( P. e ), or PBS ( n = 8 per group). The orthotopic PC model was established using Panc02 cells. ( c-d ) Demo diagram illustrating the full body, pancreas and spleen, and statistical histogram showing the fluorescent area with intensity greater than 200 photons/second (ph/s), representing pancreatic tumors in mice gavaged with E. lenta, P. excrementihominis , or PBS ( n = 8 per group). The orthotopic PC model was established using luciferase-expressing KPC1199 cells. Data are presented as mean ± SD; * P < 0.05; ** P < 0.01 by unpaired Student’s t -test

Journal: Cellular Oncology (Dordrecht, Netherlands)

Article Title: Mendelian analysis reveals novel pancreatic cancer-associated gut bacteria with tumor-suppressive effects

doi: 10.1007/s13402-025-01098-x

Figure Lengend Snippet: Effects of E. lenta and P. excrementihominis on PC. ( a-b ) Demo diagram illustrating pancreas and spleen, and statistical histograms showing pancreas weight and pancreas-to-body weight ratios in mice gavaged with E. lenta ( E. l ), P. excrementihominis ( P. e ), or PBS ( n = 8 per group). The orthotopic PC model was established using Panc02 cells. ( c-d ) Demo diagram illustrating the full body, pancreas and spleen, and statistical histogram showing the fluorescent area with intensity greater than 200 photons/second (ph/s), representing pancreatic tumors in mice gavaged with E. lenta, P. excrementihominis , or PBS ( n = 8 per group). The orthotopic PC model was established using luciferase-expressing KPC1199 cells. Data are presented as mean ± SD; * P < 0.05; ** P < 0.01 by unpaired Student’s t -test

Article Snippet: The bacteria Eggerthella lenta ( E. lenta , DSM2243), Sutterella wadsworthensis ( S. wadsworthensis , DSM14016) and Parasutterella excrementihominis ( P. excrementihominis , DSM21040) were purchased from Leibniz Institute DSMZ-German Collection of Microorganisms and Cell Cultures GmbH.

Techniques: Luciferase, Expressing